Related Publications

Targeting a Prokaryotic Protein in a Eukaryotic Pathogen: Identification of Lead Compounds against Cryptosporidiosis. N.N. Umejiego, D. Gollapalli, L. Sharling, A. Volftsun, J. Lu, N.N. Benjamin, A.H. Stroupe, T.V. Riera, B. Striepen, and L. Hedstrom (2008). Chemistry and Biology 15: 70-77.

Asher DR, Cerny AM, Finberg RW. (2005) The erythrocyte viral trap: Transgenic expression of viral receptor on erythrocytes attenuates coxsackievirus B infection. Proc Natl Acad Sci U S A. 2005 Sep 6; 102(36):12897-902. Epub 2005 Aug 25. (PubMed Abstract)

Aulinger BA, Roehrl MH, Mekalanos JJ, Collier RJ, Wang JY. (2005) Combining anthrax vaccine and therapy: a dominant-negative inhibitor of anthrax toxin is also a potent and safe immunogen for vaccines. Infect Immun. 2005 Jun; 73(6):3408-14. (PubMed Abstract)

Boll, W. M. Ehrlich, J. Collier, T. Kirchhausen.  (2004) Effects of dynamin inactivation on pathways of anthrax toxin uptake.  EJCB, 83, 281-288. (PubMed Abstract)

Cai, S., Kukreja, R., Shoesmith, S., Chang, T. Z. and Singh, B. R. (2006) Botulinum Neurotoxin Light Chain Refolds at Endosomal pH for its Translocation. Protein J.(PubMed Abstract)

Chandran K, Sullivan NJ, Felbor U, Whelan SP, Cunningham JM. (2005) Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science. 2005 Jun 10; 308(5728):1643-5. Epub 2005 Apr 14. (PubMed Abstract)

Dudek T, Knipe DM. Replication-defective viruses as vaccines and vaccine vectors. Virology. 2006 Jan 5;344(1):230-9. (PubMed Abstract)

Feng, Y. A.P. Jadhav, C. Rodighiero, Y. Fujinaga, T. Kirchhausen, W.I. Lencer.  (2004).  Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells.  EMBO Reports, 5(6), 596-601. (PubMed Abstract)

Finberg RW, Knipe DM, Kurt-Jones EA. Herpes simplex virus and toll-like receptors. Viral Immunology 2005;18:457-65. (PubMed Abstract)

Finberg RW, Kurt-Jones EA. Viruses and Toll-like Receptors. Microbes and Infection. 2004; 1356-60. (PubMed Abstract)

Finberg RW, Kurt-Jones EA.(2006) CD14: chaperone or matchmaker? Immunity. 2006 Feb;24(2):127-9. (PubMed Abstract)

Greenough TC, Carville A, Coderre J, Somasundaran M, Sullivan JL, Luzuriaga K, Mansfield K. (2005) Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus. Am J Pathol. 2005 Aug; 167(2):455-63. (PubMed Abstract)

Guertin, R.P., N. Harrison, Z.X. Zhou, S. McCall, F. Drymiotis. Very high field magnetization and ac susceptibility of native horse spleen ferritin. J. of Magnetism and Magnetic Materials, 308: 97-100, 2007.

Harris JB, Baresch-Bernal A, Rollins SM, Alam A, Larocque RC, Bikowski M, Peppercorn AF, Handfield M, Hillman JD, Qadri F, Calderwood SB, Hohmann E, Breiman RF, Brooks WA, Ryan ET.(2006)Identification of In Vivo-Induced Bacterial Protein Antigens during Human Infection with Salmonella enterica Serovar Typhi.Infect Immun. 2006 Sep;74(9):5161-8.(PubMed Abstract)

Harrison R, Trujillo C, Tamayo A, & Murphy JR. Host cell factors involved in diphtheria toxin catalytic domain entry into eukaryotic cells. In Crossroads between bacterial protein toxins and host cell defenses. (Fiorentini C, and Fabbri A, eds.) 2006; pp. 17-41.

He Y, Li J, Li W, Lustigman S, Farzan M, Jiang S.(2006) Cross-neutralization of human and palm civet severe acute respiratory syndrome coronaviruses by antibodies targeting the receptor-binding domain of spike protein.J Immunol. 2006 May 15;176(10):6085-92. (PubMed Abstract)

He Y, Zhou Y, Liu S, Kou Z, Li W, Farzan M, Jiang S. (2004) Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccine. Biochem Biophys Res Commun. 2004 Nov 12; 324(2):773-81. (PubMed Abstract)

Hu PQ, Tuma-Warrino RJ, Bryan MA, Mitchell KG, Higgins DE, Watkins SC, Salter RD. Escherichia coli expressing recombinant antigen and listeriolysin O stimulate class I-restricted CD8+ T cells following uptake by human APC. J Immunol. 2004 Feb 1;172(3):1595-601. (PubMed Abstract)

Hung DT, Shakhnovich EA, Pierson E, Mekalanos JJ (2005)  Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization. Science. 2005 Oct 28;310(5748):670-4. (PubMed Abstract)

Jin Xie,Chenjie Xu, Zhichuan Xu, Yanglong Hou, Kaylie L. Young, S. X. Wang, N. Pourmond, and Shouheng Sun (2006) Linking Hydrophilic Macromolecules to Monodisperse Magnetite (Fe3O4) Nanoparticles via Trichloro-s-triazine. Chem. Mater. 2006, 18, 5401-5403

Keefe D, Shi L, Feske S, Massol R, Navarro F, Kirchhausen T, Lieberman J. (2005)Perforin Triggers a Plasma Membrane-Repair Response that Facilitates CTL Induction of Apoptosis.Immunity. 2005 Sep; 23(3):249-62. (PubMed Abstract)

Kirchhausen T, Boll W, van Oijen A, Ehrlich M. (2005) Single-molecule live-cell imaging of clathrin-based endocytosis.Biochem Soc Symp. 2005 ;( 72):71-76. (PubMed Abstract)

Krantz BA, Finkelstein A, Collier RJ. Protein Translocation through the Anthrax Toxin Transmembrane Pore is Driven by a Proton Gradient. J Mol Biol. 2006 Feb 3;355(5):968-79. Epub 2005 Dec 1. (PubMed Abstract)

Krantz BA, Melnyk RA, Zhang S, Juris SJ, Lacy DB, Wu Z, Finkelstein A, Collier RJ.(2005) A phenylalanine clamp catalyzes protein translocation through the anthrax toxin pore.Science.2005 Jul 29;309(5735):777-81. (PubMed Abstract)

Kuhn, J. H., S. R. Radoshitzky, W. Li, S. Kee Wong, H. Choe, and M. Farzan. (2006) The SARS Coronavirus RECEPTOR ACE2 – A potential Target for Antiviral Therapy, pp. 397-418 (chapter 3.1). In Bogner, Elke, and Andreas Holzenburg (eds.), New Concepts of Antiviral Therapy, Springer, Dordrecht, The Netherlands.

Kuhn JH, Radoshitzky SR, Guth AC, Warfield KL, Li W, Vincent MJ, Towner JS, Nichol ST, Bavari S, Choe H, Aman MJ, Farzan M. (2006) Conserved receptor-binding domains of lake Victoria marburgvirus and zaire ebolavirus bind a common receptor. J Biol Chem. 2006 Apr 4 (PubMed Abstract)

Kuhn JH, Li W, Choe H, Farzan M. (2004) Angiotensin-converting enzyme 2: a functional receptor for SARS coronavirus. Cell Mol Life Sci. 2004 Nov; 61(21):2738-43. (PubMed Abstract)

Kurt-Jones EA, Sandor F, Oritz Y, Bowen GN, Counter SL, Wang TC, Finberg RW. Use of Murine Embryonic Fibroblasts to Define Toll-like Receptor Activation and Specificity. J Entox Res 2004; 419-24. (PubMed Abstract)

Kukreja, R., Sharma, S., Cai, S. and Singh, B. R. (2006) Role of Two Active Site Glu Residues in the molecular Action of botulinum neurotoxin endopeptidase. Accepted for publication in BBA.

Latz E, Visintin A, Espevik T, Golenbock DT. (2004) Mechanisms of TLR9 activation. J Endotoxin Res. 2004;10(6):406-12. (PubMed Abstract)

Li F, Berardi M, Li W, Farzan M, Dormitzer PR, Harrison SC.(2006) Conformational states of the severe acute respiratory syndrome coronavirus spike protein ectodomain.J Virol. 2006 Jul;80(14):6794-800.
(PubMed Abstract)

Li F, Li W, Farzan M, Harrison SC. (2005) Structure of SARS coronavirus spike receptor-binding domain complexed with receptor. Science. 2005 Sep 16;309(5742):1864-8. (PubMed Abstract)

Li W, Greenough TC, Moore MJ, Vasilieva N, Somasundaran M, Sullivan JL, Farzan M, Choe H. (2004) Efficient replication of severe acute respiratory syndrome coronavirus in mouse cells is limited by murine angiotensin-converting enzyme 2. J Virol. 2004 Oct; 78(20):11429-33. (PubMed Abstract)

Li W, Swee-Kee Wong, Fang Li, Jens H. Kuhn, I-Chueh Huang, Hyeryun Choe, and Michael Farzan. 2006. Animal Origins of the Severe Acute Respiratory Syndrome Coronavirus: Insight from ACE2-S-Protein Interactions. Journal of Virology (Washington, D.C.) 80(9): 4211-4219.(PubMed Abstract)

Li W, Zhang C, Sui J, Kuhn JH, Moore MJ, Luo S, Wong SK, Huang IC, Xu K, Vasilieva N, Murakami A, He Y, Marasco WA, Guan Y, Choe H, Farzan M. (2005) Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2. EMBO J. 2005 Apr 20; 24(8):1634-43. Epub 2005 Mar 24. (PubMed Abstract)

Li Z, Zhao X, Higgins DE, Frankel FR. Conditional lethality yields a new vaccine strain of Listeria monocytogenes for the induction of cell-mediated immunity. Infect Immun. 2005 Aug;73(8):5065-73. (PubMed Abstract)

Massol, R.H., J.E. Larsen, Y. Fujinaga, W. I. Lencer, T. Kirchhausen.  (2004)  Cholera Toxin Toxicity does not require functional Arf6- and Dynamin-dependent endocytic pathways. Mol Biol of the Cell, 15, 3631-3641. (PubMed Abstract)

Melnyk RA, Hewitt KM, Lacy DB, Lin HC, Gessner CR, Li S, Woods VL Jr, Collier RJ. Structural determinants for the binding of anthrax lethal factor to oligomeric protective antigen. J Biol Chem. 2006 Jan 20;281(3):1630-5. Epub 2005 Nov 17. (PubMed Abstract)

Modis, Y., Ogata, S., Clements, D. and Harrison, S.C. Variable Surface Epitopes in the Crystal Structure of Dengue Virus Type 3 Envelope Glycoprotein  J. Virology 79: January 2005; 1223-31. (PubMed Abstract

Moore MJ, Dorfman T, Li W, Wong SK, Li Y, Kuhn JH, Coderre J, Vasilieva N, Han Z, Greenough TC, Farzan M, Choe H. (2004) Retroviruses pseudotyped with the severe acute respiratory syndrome coronavirus spike protein efficiently infect cells expressing angiotensin-converting enzyme 2. J Virol. 2004 Oct; 78(19):10628-35. (PubMed Abstract)

Murphy JR, & Harrison R. Mechanisms of bacterial protein toxin into the target cell cytosol. Drug Discovery Today: Disease Mechanisms, 2006, 3: 267-272. In Press.

Parikh, S. and Singh, B. R. (2006) Comparative Membrane Channel Size and Activity of Botulinum Neurotoxins A and E. Protein J., In Press.

Pelish HE, Peterson JR, Salvarezza SB, Rodriguez-Boulan E, Chen JL, Stamnes M, Macia E, Feng Y, Shair MD, Kirchhausen T. Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro. Nat Chem Biol. 2006 Jan;2(1):39-46. Epub 2005 Nov 20. (PubMed Abstract)

Pelish, H.E., Ciesla, W., Tanaka, N., Reddy, K., Shair, M.D., Kirchhausen, T., Lencer, W.I. (2006) The Cdc42 inhibitor secramine B prevents cAMP-induced K= conductance in intestinal epithelial cells. Biochem. Pharm. 71:1720-1726. (PubMed Abstract)

Petit CM, Melancon JM, Chouljenko VN, Colgrove R, Farzan M, Knipe DM, Kousoulas KG. (2005) Genetic analysis of the SARS-coronavirus spike glycoprotein functional domains involved in cell-surface expression and cell-to-cell fusion. Virology. 2005 Aug 11. (PubMed Abstract)

Pimental RA, Christensen KA, Krantz BA, Collier RJ.(2004) Anthrax toxin complexes: heptameric protective antigen can bind lethal factor and edema factor simultaneously. Biochem Biophys Res Commun.2004 Sep 10; 322(1):258-62. (PubMed Abstract)

Pouliot, K., N. Pan, S. Wang, S. Lu, E. Lien, and J. Goguen. 2006. Evaluation of the role of LcrV/TLR2-mediated immunomoduation in the virulence of Yersinia pestis. Infection and Immunity. This manuscript has been reviewed and ins currently in revision.

Rainey GJ, Wigelsworth DJ, Ryan PL, Scobie HM, Collier RJ, Young JA. Receptor-specific requirements for anthrax toxin delivery into cells. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13278-83. Epub 2005 Sep 1. (PubMed Abstract)

Ratts R, Trujillo C, Bharti A, vanderSpek J, Harrison R, Murphy JR. A conserved motif in transmembrane helix 1 of diphtheria toxin mediates catalytic domain delivery to the cytosol. Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15635-40. Epub 2005 Oct 17 (PubMed Abstract)

Rollins SM, Peppercorn A, Hang L, Hillman JD, Calderwood SB, Handfield M, RyanET. (2005) In vivo induced antigen technology (IVIAT). Cell Microbiol. 2005 Jan; 7(1):1-9. Review. (PubMed Abstract)

Sakhatskyy P, Wang S, Chou TH, Lu S.(2006) Immunogenicity and protection efficacy of monovalent and
polyvalent poxvirus vaccines that include the D8 antigen.Virology. 2006 Aug 17 (PubMed Abstract)

Scobie HM, Thomas D, Marlett JM, Destito G, Wigelsworth DJ, Collier RJ, Young JA, Manchester M. A soluble receptor decoy protects rats against anthrax lethal toxin challenge. J Infect Dis. 2005 Sep 15;192(6):1047-51. Epub 2005 Aug 10. (PubMed Abstract)

Scobie HM, Young JA. Interactions between anthrax toxin receptors and protective antigen. Curr Opin Microbiol. 2005 Feb;8(1):106-12. Review. (PubMed Abstract)

Scobie HM, Wigelsworth DJ, Marlett JM, Thomas D, Rainey GJ, Lacy DB, Manchester M, Collier RJ, Young JA. Anthrax toxin receptor 2-dependent lethal toxin killing in vivo. PLoS Pathog. 2006 Oct;2(10):e111 (PubMed Abstract)

Sebastian S, Dillon ST, Lynch JG, Blalock LT, Balon E, Lee KT, Comstock LE, Conlan JW, Rubin EJ, Tzianabos AO and Kasper DK. A defined O-antigen polysaccharide mutant of Francisella tularensis LVS with attenuated virulence and protective capacity. 2006. Manuscript under review (Infect Immun).

Sharma S, Zhou Y, Singh BR. (2005) Cloning, expression, and purification of C-terminal quarter of the heavy chain of botulinum neurotoxin type A.Protein Expr Purif. 2005 Sep 3; (PubMed Abstract)

Sharma, S. K. and Singh, B. R. (2004) Enhancement of the Endopeptidase Activity of Purified Botulinum Neurotoxins A and E by an Isolated Component of the Native Neurotoxin Associated Proteins, Biochemistry, 43, 4791-4798. (PubMed Abstract)

Starks H, Bruhn KW, Shen H, Barry RA, Dubensky TW, Brockstedt D, Hinrichs DJ, Higgins DE, Miller JF, Giedlin M, Bouwer HG. Listeria monocytogenes as a vaccine vector: virulence attenuation or existing antivector immunity does not diminish therapeutic efficacy. J Immunol. 2004 Jul 1;173(1):420-7. (PubMed Abstract)

Sui, J., W. Li, A. Roberts, L. J. Matthews, A. Murakami, L. Vogel, S. K. Wong, K. Subbarao, M. Farzan, and W. A. Marasco. 2005. Evaluation of human monoclonal antibody 80R for immunoprophylaxis of severe acute respiratory syndrome by an animal study, epitope mapping, and analysis of spike variants. J Virol 79:5900-6. (PubMed Abstract)

Szomolanyi-Tsuda E, Liang X, Welsh RM, Kurt-Jones EA, Finberg RW. Role for TLR2 in NK cell-mediated control of murine cytomegalovirus in vivo. Journal of Virology 2006;80:4286-91.(PubMed Abstract)

Trujillo C, Ratts R, Bharti A, vanderSpek C, Harrison R, and Murphy J. T1: A peptide motif essential for diphtheria toxin catalytic domain entry. Inter. J. Med. Micro., 2006; In Press

Trujillo C, Ratts R, Tamayo A, Harrison R, & Murphy JR. Trojan horse or proton force: Finding the right partner(s) for toxin translocation. Neurotoxicity Res, 2006; 9: 63-71.(PubMed Abstract)

Udani RA, Levy SB.(2006) MarA-Like Regulator of Multidrug Resistance in Yersinia pestis. Antimicrob Agents Chemother. 2006 Sep;50(9):2971-5.(PubMed Abstract)

Walsh, S.R. and R.P. Johnson. Vaccinia Folliculitis After Primary Dryvax Vaccination. Infectious Diseases in Clinical Practice. 2006; In Press

Wang JY, Roehrl MH. (2005) Anthrax vaccine design: strategies to achieve comprehensive protection against spore, bacillus, and toxin. Med Immunol. 2005 Mar 24; 4(1):4. (PubMed Abstract)

Wang JP, Kurt-Jones EA, Shin OS, Manchak MD, Levin MJ, Finberg RW. Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via Toll-like receptor 2. Journal of Virology 2005;79:12658-66.(PubMed Abstract)

Wolfe JT, Krantz BA, Rainey GJ, Young JA, Collier RJ. Whole-cell voltage clamp measurements of anthrax toxin pore current. J Biol Chem. 2005 Nov 25;280(47):39417-22. Epub 2005 Sep 23. (PubMed Abstract)

Xie, J., Xu, C., Xu, Z., Hou, Y., Young K.L., Wang, S.X., Pourmond, N. and S. Sun. Linking Hydrophilic Macromolecules to Monodisperse Magnetite (Fe3O4) Nanoparticles via Trichloro-s-triazine. Chemistry of Materials, 18:5401-5403, 2006.

Zhou S, Kurt-Jones EA, Mandell L, Cerny A, Chan M, Golenbock DT, Finberg RW. (2005) MyD88 is critical for the development of innate and adaptive immunity during acute lymphocytic choriomeningitis virus infection.Eur J Immunol. 2005 Mar;35(3):822-30. (PubMed Abstract)

Zhou Y, Foss S, Lindo P, Sarkar H, Singh BR. (2005) Hemagglutinin-33 of type A botulinum neurotoxin complex binds with synaptotagmin II.FEBS J. 2005 Jun; 272(11):2717-26. (PubMed Abstract)